Ultra-low-power microprocessors

Inventor(s): David Blaauw, Dennis Sylvester

Management: Scott Hanson 

Therapeutics targeting breast cancer

Inventor(s): Shaomeng Wang

Management: Dajun Wang 

Joint venture with Cambridge University for English language assessment

Inventor(s): The University of Michigan English Language Institute

Management: Casey Marks 

Tools to identify crystalline forms of active pharmaceutical ingredients

Inventor(s): Adam Matzger

Management: Adam Matzger 

Advanced battery cathode manufacturing technology

Inventor(s): Pravansu Mohanty

Management: Nicholas Cucinelli 

Static electrical field measurement device

Inventor(s): Nilton Renno, Steve Rogacki

Management: Nilton Renno 

Replacement for machining cutting fluid with CO2 emulsion

Inventor(s): Steven Skerlos

Management: Thomas Gross 

Selective threonine/serine kinase inhibitors

Inventor(s): Gary Glick

Management: David Hoffman 

Rapid cell culturing using magnetic spheres

Inventor(s): Raoul Kopelman, Brandon McNaughton

Management: Sundu Brahmasandra 

RNA screening drug research tool

Inventor(s): Hashim Al-Hashimi

Management: Michael Pape 

Photosensitizing compounds used in photodynamic cancer therapy

Inventor(s): Raoul Kopelman

Management: Ravindsa Pandey 

Crystalline structured transparent 3D scaffolds for cell culture
 (3D petri dish)

Inventor(s): Nick Kotov, Shuichi Takayama

Management: Nick Kotov  

Dense wireless sensor networks for building automation systems

Inventor(s): Jerry Lynch

Management: Andy Zimmerman 

Next-generation, high-density crossbar array for improved computer memory

Inventor(s): Wei Lu

Management: George Minassian 

Over-the-counter nutraceutical products for the prevention of noise-induced hearing loss

Inventor(s): Colleen LePrell, Josef Miller

Management: Barry Seifer 

Image-guided histotripsy system using ultrasound to excise and mechanically homogenize tissue

Inventor(s): Charles Cain

Management: Tom Davison 

Sensor-enabled sporting equipment for skill analysis and training

Inventor(s): Noel Perkins

Management: Mike Crowley  

Core facility for the discovery of MicroRNA disease biomarkers

Inventor(s): Inhan Lee

Real-time fleet management plus customer-oriented vehicle location and time-of-arrival alert functions

Inventor(s): Marc Allen, Jason Dillaman, Evan Hsu, Stephen Musko, Prasanth Pandian, Christopher Ruf

Management: Adrian Fortino  

Catheter stabilization systems for fluid/medication delivery

Inventor(s): Adrienne Harris, Elyse Kemmerer, Merrell Sami, Steven White

Management: Jeff Williams, CEO and Chairman of the Board 

Sub-surface hydrokinetic power generating devices for rivers and oceans

Inventor(s): Mike Bernitsas

Management: Gus Simiao 

Economic indicator based on customer satisfaction

Inventor(s): Claes Fornell

Management: Sheri Teodoru, CEO 

Develop bioactive, conductive polymer materials and coatings specifically tailored to enhance a wide variety of implantable medical devices

Inventor(s): David C. Martin

Investor(s): Allied Minds Inc. 

Miniature high-speed current probes

Inventor(s): Raul Kopelman

Device for early non-invasive detection of retinal and metabolic diseases

Inventor(s): Vic Elner, Howard Petty

Investor(s): VC Seed Round

Management: Kurt Reigger 

Treatment for symptoms of DMD and heart failure

Inventor(s): Joseph Metzer

Management: Leslie Browne, President & CEO 

Device to prevent esophageal thermal injury during catheter ablation procedures

Inventor(s): Hakan Oral

Health monitoring products that interface directly with human skin

Inventor(s): Joerg Lahann

Investor: Flagship

Management: Jim Matheson 

Tools for searching clinical documents

Inventor(s): David Hanauer

Compact, high-power fiber lasers for industrial and life science applications

Inventor(s): Almantas Galvanauskas

Investor(s): RPM Ventures, Undisclosed Strategic Investor

Management: Phil Amaya, CEO 

Cancer diagnostic utilizing microarray autoantibody signatures

Inventor(s): Arul Chinnaiyan

Investor(s): Apjohn Group

Management: Eli Thomssen, CEO 

Treatment of inflammation-based diseases and conditions using selective cytopheresis system (Formerly: Nephrion)

Inventor(s): H. David Humes

Investor(s): Apjohn Ventures, Diamond Capital Management, Lurie Investments Inc., North Coast Technology Investors LP, Western Michigan University

Management: Jim Danehy, CEO; David Humes, CSO 

Advanced water scale packaging for MEMS devices

Inventor(s): Khalil Najafi

Management: Jay Mitchell, CEO 

Cell-based therapies for diabetic ulcers

Inventor(s): Elliott Hill

Management: Alfred Vasconcellos 

Monoclonal antibody therapies against sepsis

Inventor(s): Peter A. Ward

Investor(s): Affentranger Associates, Beteiligungs-Management

Management: Niels C. Riedemann, CEO 

Treatments for autoimmune diseases

Inventor(s): Gary D. Glick

Investor(s): ARCH Venture Partners, Clarus Ventures, EDF Ventures, InterWest Partners 

Applications of lasers for tissue ablation and infrared counter measures

Inventor(s): Mohammed N. Islam

Management: Gerald Roston, GM; Mohammed Islam, CTO 

Drugs and therapies for prevention of hearing loss

Inventor(s): Josef M. Miller

Management: Josef Miller, President and Interim CEO

Investor(s): SWMF Life Science Fund 

Cannulated scalpels for use in bone fracture repair

Inventor(s): Steven Goldstein

Management: Herbert Huddlesten, CEO 

Drive-train batteries for next generation transportation

Inventor(s): Ann Marie Sastry

Investor(s): Khosla Venutres

Management: Ann Marie Sastry, CEO 

Systems & materials to create living joints and other bone replacements

Inventor(s): David J. Mooney

Investor(s): Venture Investors

Management: Jim Adox, Acting CEO 

Reporting software system for electrophysiology analysis

Inventor(s): Frank Pelosi

Management: Erdwing Coronado, CEO 

MEMS technology for creating morphing wing & turbine blade surfaces

Inventor(s): Sridhar Kota

Software for medical imaging

Inventor(s): Brian Ross, Alnawaz Rehemtulla

Management: Danny J. Cunagin, CEO; Troy Kopischke, President & COO 

Microfluidic devices for premium cell management

Inventor(s): Shuichi Takayama, Gary Smith

Investor(s): Angel Healthcare Investors, Fenwick & West, Plymouth Venture Partners, Venture Investors

Management: Christopher Bleck, President & CEO

Acquired By: Origio 

Software for managing extremely large databases of geospatial information

Inventor(s): Jignesh M. Patel

Custom DNA and peptide arrays synthesized on open surfaces (Formerly: BioDiscovery, LLC)

Inventor(s): Erdogan Gulari

Highly mobile mechanical robots

Inventor(s): Daniel Koditschek, Uluc Saranli, Martin Buehler

Developing treatments for inflammatory, fibrotic & neurologic diseases (Formerly: Pipex Pharmaceuticals, Inc.)

Inventor(s): George J. Brewer

Investor(s): Accredited Venture Capital LLC, AFA Private Equity of Michigan, Chestnut Ridge Partners, Firebird Capital, Perceptive Life Sciences Fund, Ridgeback Capital, SDS Capital, Gemini Strategies, Whalehaven Capital, Accredited Equities Inc., William Harris Investors (WHI)

Management: Steve Kanzer, CEO

IPO: 2007 [AMEX: PP] 

Fly casting training aid using MEMS gyros and software

Inventor(s): Noel C. Perkins

Management: Noel Perkins, Bruce Richards 

Software and IT services for primary care health providers

Inventor(s): Lee Green, Donald E. Nease, Jr., Mike Klinkman

Investor(s): Altarum

Management: David Morin, President & CEO

Acquired By: The Advisory Board Company [NASDAQ: ABCO] in 2011 

Molecular oncology tools, data, and analysis software

Inventor(s): Arul Chinnaiyan, Dan Rhoades

Management: Dan Rhodes, CEO 

Ultra-low power semiconductor chips

Inventor(s): Marios Papaefthymiou, Alexander Ishii

Investor(s): Modal Perdana, Siemens Technology to Business Center 

Grain refinement technology for magnesium and other metals

Inventor(s): Amit K. Ghosh

Management: Steve LeBeau, President & CEO 

Using gene-based molecular diagnostics for the early detection of HPV

Inventor(s): David M. Kurnit, Bruce C. Richardson

Investor(s): Ann Arbor SPARK, Delaware Crossing

Management: Shawn Marcell, President & CEO

Acquired By: Sequenom [NASDAQ:SQNM] in 2009 

Global virtual cable network bringing live TV to the internet

Inventor(s): Sugih Jamin

Investor(s): Undisclosed Swiss Private Equity

Management: Beat Knetch, CEO 

Cell analysis instruments

Inventor(s): Steven J. Skerlos

Investor(s): Ann Arbor Angels, Arboretum Ventures, Baird Venture Partners, Core Network, Fidelity Biosciences, Flagship Ventures, Great Lakes Angels

Management: Jeff Williams, President and CEO

Acquired By: Becton Dickinson [NYSE: BDX] in 2011  

Nuclear cardiology imaging software

Inventor(s): James R. Corbett, Edward Ficaro

Management: James R. Corbett, Chairman; Edward Ficaro, President 

Multifunctional organic/inorganic nanocomposites for coatings and thin film technologies

Inventor(s): Richard M. Laine

Management: Richard Laine, CEO 

Software for pharmacy applications

Inventor(s): Scott R. McCreadie, Barbara R. McCreadie

Small, point-of-care Computed Tomography scanners for medical-imaging

Inventor(s): Neal H. Clinthorne

Management: Predrag Sukovic, CEO 

Cardiac therapeutic devices

Inventor(s): Hakan Oral

Investor(s): Aberdare Ventures, Affinity Ventures, Hexagon Investments, Novartis Bioventures, Pequot Ventures, Trellis Health Ventures, Venture Lending & Leasing III, Versant Ventures, WS Investment Company

Management: Keegan Harper, CEO

Acquired By : Medtronic [NYSE:MDT] in 2009  

Developing coatings for blood-contacting medical devices

Inventor(s): Mark Meyerhoff, Joerg Lahann

Investor(s): Arboretum Ventures, MC3 Corp., Sigvion Capital

Management: Kris Aalto, CEO 

Small-molecule oncology therapeutics focusing on compounds that induce apoptosis (cell death) in tumor cells

Inventor(s): Shaomeng Wang

Investor(s): Domain Associates, Enterprise Partners, Pac-Link, Perseus LLC, Sofinnova Ventures, Scale Venture Partners, US Venture Partners

Management: Mel Sorensen, CEO 

Cancer detection and treatment therapeutics

Inventor(s): James R. Baker

Medical imaging and therapeutic agents

Inventor(s): Raymond E. Counsell

Investor(s): Advantage Capital Partners, Continuum Investment Partners, Venture Investors LLC

Management: Bill Clarke, President & CEO 

Chemical and biological approaches to regeneration and remineralization of dental, oral & craniofacial tissues

Inventor(s): David J. Mooney

Management: Chris Somogyi

Acquired By: Ivoclar Vivadent AG in 2003 

Semiconductor technology focused on mixed-signal integration

Inventor(s): Richard B. Brown, Michael McCorquodale

Investor(s): Foundation Capital, Menlo Ventures, RPM Ventures

Management: Ashok Dhawan, CEO

Acquired By: IDT [NASDAQ: IDTI] in 2010 

Intravascular treatment for brain vessel defects

Inventor(s): Daryl A. Kipke, David J. Mooney

Management: Daryl Kipke, President & CEO

Acquired By: W.L. Gore in 2006 

Implantable, microscale neural probes

Inventor(s): Kensall D. Wise

Management: Daryl Kipke, President & CEO 

Drugs for MS, cancer and tuberous sclerosis

Inventor(s): Kun-Liang Guan

Specializing in products and services for RF, microwave and millimeter-wave measurements and diagnostics

Inventor(s): John F. Whitaker

Molecular medicine for the detection and treatment of cancer (Formerly: MetaProbe & Alerion Biomedical)

Inventor(s): Ray Counsell

Investor(s): IngleWood Ventures, Research Corporation Technologies, Scope Industries

Management: Sebastien Gignac, Chairman, President & CEO

Acquired By: Advanced Research Technologies, Inc. [TSX:ARA] in 2006 

Imaging devices for diagnosis of vascular plaques

Inventor(s): Richard L. Wahl

Management: Farhad Daghighian, President & CSO 

Vaccine development using novel adenovirus vectors

Inventor(s): Jeffrey Chamberlain, Michael J. Imperiale

Management: Frank Jones, Chairman & CEO 

Tracking and scheduling program for medical residents

Inventor(s): Paul Gauger, Thomas C. May, Peter Orr

Management: Peter Orr, CEO 

Concrete additive for strength and durability

Inventor(s): Antoine E. Naaman

Management: Bill Orabone 

Intelligent systems for defense, government, and commercial applications that emulate human decision making

Inventor(s): David Kieras, Karen Coulter, Randolph Jones, Frank Koss, John Laird

Management: Mike VanLent, President, CEO & Chief Scientist 

Proteomics utilizing liquid-based protein separations

Inventor(s): David M. Lubman

Management: Tim Barder, President & CEO 

State-of-the-art intelligence sensing and data analysis techniques

Inventor(s): William J. Williams

Management: Mitchell Rohde 

Developing novel therapies for osteoporosis and other bone diseases

Inventor(s): Michael W. Long

Management: Michael W. Long, President & CEO 

Internet denial of service protection tools

Inventor(s): Farnam Jahanian, G. Robert Malan

Investor(s): Battery Ventures, Cisco Systems, Comcast Interactive Capital, EDF Ventures, Ironside Ventures, SAIC Venture Capital Corporation, Thomas Weisel Venture Partners

Management: Jack Boyle, CEO; Harry Wan, CTO (Ann Arbor)

Acquired By: Tektronix Communications (Danaher Corporation) [NYSE: DHR] in 2010 

MEMS-based transceivers and related devices for frequency and timing control solutions

Inventor(s): Clark T.C. Nguyen

Investor(s): 3i Group, Ardesta LLC, Horizon Ventures, Lurie Investments, Partech International, Qualcomm Ventures, Scale Venture Partners, W Capital Partners

Management: Bruce Diamond, President & CEO 

Educational technologies improving K-12 education

Inventor(s): Stephan W. Burdick, Elliot Soloway

Management: Elliot Soloway, CEO 

Interactive cell-based dressing for the treatment of chronic wounds

Inventor(s): Riley S. Rees

Investor(s): KD Investments

Management: Gretchen Johnson, President & CEO 

Imaging intracellular events (Formerly: Molecular Therapeutics)

Inventor(s): Raoul Kopelman, Brian D. Ross

Management: W.R. "Dick" Leopold, President & CEO

Acquired By: Charles River Laboratories International, Inc. [NYSE:CRL] in 2008 

Non-toxic solvent-detergent lipid suspensions with antimicrobial properties

Inventor(s): James R. Baker

Investor(s): Perseus LLC

Management: Dave Peralta, CFO & COO; James Baker, Executive Chairman & CEO 

Biological therapeutics targeting cancer stem cells

Inventor(s): Michael F. Clarke, Max S. Wicha

Investor(s): Adams Street Partners, Bay Partners, Delphi Ventures, De Novo Ventures, Genentech, GlaxoSmithKline, Latterell Venture Partners, Morgenthaler Ventures, Nomura Phase4 Ventures, US Venture Partners, The Vertical Group

Management: Paul Hastings, President & CEO 

Discovering molecular origins of complex disorders using integrated array techniques

Inventor(s): Huda Akil, Michael D. Uhler

Management: Alfred Mansour, President & CEO 

Advancing water testing technology

Inventor(s): Richard B. Brown

Investor(s): Ardesta, LLC, Firelake Capital Management, NGEN Partners, Technology Partners, Topspin Partners

Management: Malcolm Kahn, CEO

Acquired By: General Electric [NYSE:GE] in 2008 

Advanced glass micromachining providing new ways to advance sensing, microfluidic and optical communication capabilities

Inventor(s): Peter P. Pronko

Investor(s): Ardesta LLC, Avalon Technology Ventures, Michigan 21st Century Jobs Fund

Management: Phillippe Bado, President & CTO 

Microarray nucleic acid processing chip

Inventor(s): Erdogan Gulari

Acquired By: Invitrogen in 2004 

Developing novel clinical diagnostic testing products to improve infectious disease testing

Inventor(s): Mark A. Burns

Investor(s): Ardesta LLC, Arboretum Ventures, Dow Ventures, DuPont Ventures, EDF Ventures, Pfizer Strategic Investments, SBV Venture Partners, Trillium Ventures, Wolverine Venture Fund

Management: Jeff Williams, President & CEO

Acquired By: Becton Dickinson [NYSE: BDX] in 2009 

Provides Authentication, Authorization, and Accounting (AAA) systems to secure access to wireless and wired networks

Inventor(s): John R. Vollbrecht

Investor(s): Arbor Partners, Duchossors Technology Partners, Intel Capital, M-Group, Mustang Ventures, Nokia Internet Communications, Siemens Venture Capital

Management: Roger Burgett, CEO 

Provides WiFi mobility and networking protocol software for the wired and wireless communications market (Formerly: Djinesys, Inc)

Inventor(s): Susan K. Hares

Investor(s): Duchossis Technology Partners, Labrador Ventures, New Enterprise Associates, Parker Price Venture Capital

Acquired By: U4EA Technologies in 2008 

Amplification technologies for molecular diagnostics and research

Inventor(s): David G. Beer, John C. Drach, John P. Langmore

Investor(s): Duchossois Technology Partners, ARCH Development Partners and Sloan Ventures

Management: James Koziarz 

Optical networking transport solutions for regional, long-haul and ultra-long-haul networks

Inventor(s): Mohammed N. Islam

Investor(s): Accel Partners, ARCH Venture partners, Atlas Venture, Berkeley International, CenterPoint Ventures, ComVentures, CSK Venture Capital, EDF Ventures, Hook Partners, InterWest Partners, J.P. Morgan Partners, New Enterprise Associates, Questar, Rho Management, Sevin Rosen, Star Ventures, TVM Capital, Wellcome Trust of London

Management: Jon Hopper, CEO 

Ultrafast laser systems

Inventor(s): Steven Kane, Peter P. Pronko

Management: Bill Clark, President & CEO 

Delivers tailored behavioral support programs to health management organizations and pharmaceutical companies

Inventor(s): Vic Strecher

Investor(s): Arboretum Ventures, Ardesta, Avalon Capital Group, AvTech Ventures, Chrysalis Ventures, Princeton Fund

Management: Sanjay Gupta, CEO

Acquired By: Johnson & Johnson [NYSE:JNJ] in 2008 

Advanced micro-machining technologies for medical devices and scientific analytical sensing applications

Inventor(s): Khalil Najafi, Kensall D. Wise

Management: Nader Najafi, President & CEO 

Medical device company that developed an automated procedure for laser vision correction, procedure known as "IntraLasik" or "Bladeless Lasik"

Inventor(s): -

IPO: 2004 [NASDAQ:ILSE], Acquired by Advanced Medical Optics [NYSE:EYE] in 2007, Abbott [NYSE:ABT] in 2009 

Oxide ceramics and nanopowders

Inventor(s): Richard M. Laine

Investor(s): Ann Arbor Angels, Arbor Partners, Great Lake Angels, Valenti Capital

Management: Steve Swanson, Chairman & CEO; Peter Gray, President & COO 

Machine vision intelligent systems

Inventor(s): Yi L. Murphey

CardioGene is focused on the development of novel gene therapy products for the treatment of cardiovascular disease (Formerly: Genocor, Inc.)

Inventor(s): Jeffrey M. Leiden, Betsy Nabel, Gary Nabel

Management: Martin Cleary, President & CEO

Acquired By: Boston Scientific [NYS:BSX] in 1998 

Light Detection and Ranging (LIDAR) and related optical systems for atmospheric measurement

Inventor(s): Paul B. Hays

Management: Peter Tchoryk, CEO 

Run-to-run controllers for semiconductors

Inventor(s): James Moyne

Management: James Moyne, President & CEO

Acquired By: Brooks Automation [NASDAQ:BRKS] in 2000 

Commercializing Mammastatin Serum Assay technology used to screen breast cancer risk

Inventor(s): Paul R. Ervin

Acquired By: Genesis Bioventures [AMEX:GBI] in 2001, now Abviva [OTC;ABVV] 

High-speed optical sensing devices

Inventor(s): Steven L. Williamson

Management: Richard Kurtz, CEO

Acquired By: Advanced Photonics, Inc. [AMEX:API] in 2005 

Therapeutic applications focused on inhibiting caspase activity as treatments for liver disease and inflammation

Inventor(s): Gabriel Nunez

Investor(s): Aberdare Ventures, Abbott Laboratories, Accel Partners, ARCH Venture Partners, BioVeda Capital, Delphi Ventures, Elan International Services, GeneChem, Hambrecht & Quest Capital Management, Institutional Venture Partners & Affiliated Entitites, MPM Capital, Novartis Pharma AG, Pacific Rim Ventures, Prospect Venture Partners, RBC Capital Partners, Sorrento Venture, Sutter Hill Ventures, Temasek Holdings, Venrock Associates, Ventana Capital Management

Management: Steven Mento, President & CEO

Acquired By: Pfizer, Inc. [NYSE:PFE] in 2005 

Molecular medicines for disease detection and prevention (Formerly: Genevo)

Inventor(s): James M. Wilson

Investor(s): Biogen, Inc., Dompe Pharmaceuticals

Management: Eric Aguiar

Acquired By: Targeted Genetics, Inc. [NASDAQ; TGEN] in 2000 

Research and genetic disease detection services for all purebred animals

Inventor(s): George J. Brewer

Management: Ray Royal, President & CEO 

Digital audio compression system

Inventor(s): David J. Anderson

Developing immunomodulatory & anti-inflammatory therapeutics based on cell adhesion technology

Inventor(s): John B. Lowe

Investor(s): Delphi Ventures

Acquired By: Cytel Corp [NASDAQ:CYTL] in 1991, Neose [NASDAQ; NTEL] in 1999, NovoNordisk [NYSE:NVO] in 2008  

Optical imaging using in-situ thin-film and wafer characterization technologies

Inventor(s): Darryl Barlett, Roy Clarke

Management: Darryl Barlett, General Manager; Roy Clarke, President 

Microcarriers and protocols for cell culture applications

Inventor(s): James Varani

Management: Dave Solomon, CEO; William Hillegas, EVP & CSO 

Developing autologous stem cell products for use in regenerative medicine

Inventor(s): Bernhard O. Palsson

Investor(s): EDF Ventures

Management : Timothy M. Mayleben, CEO

IPO: 1997 [NASDAQ:ASTM] 

Discovering and developing drugs for oncology, inflammation, immunology, & metabolic diseases

Inventor(s): Craig R. Halberstadt, Willfried Schramm

Management: Bassam B. Damaj, CEO & CSO; Henry Esber, SVP, CBO, & Chairman 

Developing drug delivery solutions

Inventor(s): Gordon L. Amidon

Management: John Hilfinger, Executive Vice President & General Manager